Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
نویسندگان
چکیده
منابع مشابه
The neurotrophin receptors TrkA and TrkC but not TrkB cause neuronal death
Biozentrum, University of Basel, CH-4056 Basel, Switzerland; Helmholtz Zentrum München, Institute of Stem Cell Research, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany; Instituto Cajal, CSIC, Avda Dr Arce 37, E-28002 Madrid, Spain; Neurodegeneration Department, Neuroscience Research, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland 5 present address: Novartis Pha...
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Current therapies for treating skeletal pain have significant limitations as available drugs (non-steroidal anti-inflammatory drugs and opiates) have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomysin receptor kinase A (TrkA) has recently become an attractive target for inhibition of adult skeletal pain. Here we explore whether sustained ad...
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The Trk family of protein tyrosine kinases (TrkA/B/C) are receptors for neurotrophins, a family of closely related proteins that are important physiological regulators of the survival of specific neurons within the peripheral nervous system (PNS) of vertebrates. In contrast to the PNS, brains of mutant mice deficient in a single neurotrophin or Trk receptor species do not show signs of major ce...
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Neurotrophins control neuronal survival in a target-derived manner during the period of naturally occurring cell death in development. The specificity of this mechanism has been attributed to a restricted spatio-temporal expression of neurotrophin ligands in target tissues, as well as a selective expression of their cognate tyrosine kinase (Trk) receptors in different neuronal subpopulations. H...
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Spinal sensory ganglia have been shown to contain neuronal subpopulations with different functions and neurotrophin dependencies. Neurotrophins act, in large part, through Trk receptor tyrosine kinases: nerve growth factor (NGF) via TrkA, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via TrkC. In the present paper, we use antibodies t...
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature09336